DETAILED NOTES ON FENTANYL OVERDOSE SYMPTOMS AND CAUSES

phenytoin will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead into a lessen in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, advancement of a withdrawal syndrome within a affected